alifpharma

Secnid DS

Product Code: 1812

TK : 50 (2 tablets)


COMPOSITION
Secnid® DS tablet : Each aromatic film coated tablet contains
secnidazole INN 1000 mg.
Secnid® 500 mg susp. : Dry granules for oral suspension equivalent to
secnidazole INN 500 mg in a single dose bottle.
PHARMACOLOGY
Secnidazole is the first nitroimidazole to offer a 3-day antiprotozoal activity
from one single dose. With its prolonged half life, Secnid® (secnidazole)
offers an effective treatment and thus ensures improved patient compliance
because of the short duration of treatment with excellent therapeutic
efficacy.
Secnid® (secnidazole) exhibits activity against anaerobic protozoa
Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis.
Secnid® (secnidazole) is rapidly absorbed following oral administration. The
maximum serum level is obtained after 3 hours following oral administration
of 2 gm secnidazole.
The plasma elimination half life is about 20 hours. The majority of Secnid®
(secnidazole) is eliminated via urine (50% of the ingested dose is excreted
within 120 hours).
The pharmacokinetic profile of Secnid® (secnidazole) gives it the longest
half-life of all the second generation nitroimidazoles, ensuring 72-hour
therapeutic blood levels from a 2 gm single dose.
INDICATION
1. Intestinal Amoebiasis
2. Hepatic Amoebiasis
3. Urethritis and Vaginitis due to Trichomonas vaginalis
4. Giardiasis
DOSAGE AND ADMINISTRATION
Secnid® (secnidazole) tablet should be administered orally. The dosage
schedule of Secnid® (secnidazole) tablet is mentioned below :
Secnidazole
Amoebicide
Secnid®
ANTIPROTOZOALS
Secnid® DS
Amoebiasis :
Acute intestinal amoebiasis :
Adults: 2 gm single dose (2x1000 mg tablet), taken preferably just before
meal.
Children: 30 mg/kg single dose, taken preferably just before meal.
Asymptomatic amoebiasis (minute & cystic form) :
Adults: 2 gm once daily (2x1000 mg tablet) for only 3 days, taken preferably
just before meal.
Children: 30 mg/kg once daily for only 3 days, taken preferably just before
meal.
Hepatic amoebiasis :
Adults: 1.50 gm/day, in a single or divided dose, just before meal for 5 days.
Children: 30 mg/kg/day, in a single or divided dose, just before meal for 5
days.
N.B.: Evacuation of pus must be performed simultaneously with Secnid®
(secnidazole) treatment at the suppurative stage of hepatic amoebiasis.
Giardiasis :
Adults: 2 gm single dose (2x1000 mg tablet), taken preferably just before
meal.
Children: 35-50 mg/kg single dose, taken preferably just before meal.
Trichomoniasis :
Adults: 2 gm single dose (2x1000 mg tablet), taken preferably just before
meal.
Children: 30 mg/kg single dose, taken preferably just before meal.
The partner should also receive the same treatment concomitantly.
Secnid® Suspension
Secnid® suspension should be administered orally. The dosage schedule of
Secnid® suspension is mentioned below:
Children of 10 to 15 kg body weight: 1 bottle of Secnid® 500 mg suspension.
Children of 16 to 25 kg body weight: 11/2 bottle of Secnid® 500 mg
suspension.
Children of 26 kg or more body weight: 2 bottles of Secnid® 500 mg
suspension.
Secnid®
ANTIPROTOZOALS
CONTRAINDICATION AND PRECAUTION
Secnidazole is contraindicated for those patients who are hypersensitive to
imidazole derivatives.
Patients should be advised not to take alcohol during treatment with
secnidazole (because of possibility of antabuse effect). Administration of
secnidazole should be avoided to patients with a history of blood dyscrasia.
SIDE EFFECT
The clinical studies have shown that secnidazole is characterized by very
good tolerance and no serious adverse reactions have been reported to
date.
The following side-effects may be observed with secnidazole as with all
nitroimidazole derivatives & are rarely serious
Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric
pain, metallic taste, glossitis, and stomatitis.
Occasional side-effects: Urticaria, moderate leukopenia which is reversible
on treatment discontinuation.
Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, and
peripheral neuropathy.
With secnidazole, gastrointestinal disorders e.g. nausea, vomiting, epigastric
pain, etc. have been reported in very rare cases.
DRUG INTERACTION
Administration of secnidazole with disulfiram is not recommended:
confusional state & paranoid reaction may occur. Use of secnidazole
simultaneously with warfarin requires close monitoring: increased effect of
oral anticoagulants and of the hemorrhagic risk is likely.
USE IN PREGNANCY AND LACTATION
Secnidazole may be prescribed in pregnancy after the first trimester. As with
other similar drugs, secnidazole should not be administered during the first
trimester of pregnancy or during lactation because secnidazole is found in
placenta and breast milk.
Secnid®
ANTIPROTOZOALS
STORAGE CONDITION
Store in a cool dry place, protected from heat.
HOW SUPPLIED
Secnid® DS tablet : Box containing 5 x 2 Secnid® DS tablets in
blister pack.
Secnid® 500 mg suspension : Bottle containing dry granules for oral
suspension equivalent to secnidazole INN
500 mg.
Secnid®
ANTIPROTOZOALS

Brand: Square Pharmaceuticals Ltd


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