Cholecalciferol is a synthetic form of Vitamin D3. Vitamin D is important for the absorption of Calcium from the stomach and for the functioning of Calcium in the body. Cholecalciferol is used to treat or prevent many conditions caused by a lack of Vitamin D, especially conditions of the skin or bones. Cholecalciferol helps our body to utilize both Calcium and Phosphorus by acting like a hormone.
Cholecalciferol is indicated in the prevention and treatment of Vitamin D deficiencies. It is also indicated for osteoporosis, osteomalacia, hypocalcaemia, tetany, rickets, preeclampsia, eclampsia, prediabetes etc.
Mode of Action:
The active form of Vitamin D binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the Vitamin D receptor has hormone-binding and DNA-binding domains. The Vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which Vitamin D suppresses transcription.
Brand: Opsonin Pharma Limited