Parotin 10mg

Product Code: 4072

TK : 181 (30 Tablets)


Parotin® is a preparation of Paroxetine which is a potent and selective inhibitor of 5-
hydroxytryptamine (5-HT, serotonin) uptake. Paroxetine works by enhancing the
serotonergic activity in the central nervous system resulting from inhibition of neuronal
reuptake of serotonin (5-hydroxytryptamine, 5-HT), in addition with blocking the reuptake
of serotonin into human platelets and has only very weak effects on norepinephrine and
dopamine neuronal reuptake.
Indication and usage
Parotin® is indicated for -
Major depressive disorder ● Obsessive compulsive disorder
Panic disorder ● Generalized anxiety disorder
Social anxiety disorder ● Post-traumatic stress disorder
Dosage and administration
● Major depression, social anxiety disorder, post-traumatic stress disorder, generalized
anxiety disorder: The recommended dose is 20mg daily, usually to be taken in the morning
and maximum dose up to 50mg daily.
● Obsessive-compulsive disorder: The initial dose is 20mg daily, usually to be taken in the
morning and maximum dose up to 60mg daily.
● Panic disorder: The initial dose is 10mg daily, usually to be taken in the morning and
maximum dose up to 60mg daily.
The maximum dose for elderly is 40mg daily.
Children under 18 years
Paroxetine is not recommended.
Use in pregnancy and lactation
Paroxetine should only be used during pregnancy when strictly indicated. Abrupt
discontinuation should be avoided during pregnancy. Neonates should be observed if
maternal use of paroxetine continues into the later stages of pregnancy, particularly the
third trimester.
Small amount of Paroxetine are excreted into breast milk and caution should be exercised
when Paroxetine is administered to a nursing woman. In published studies, as no sign of
drug effects were observed in infants, breast-feeding can be considered.
Side effects
The most common side effects are somnolence, insomnia, agitation, abnormal dreams
(including nightmares), increases in cholesterol levels, decreased appetite, dizziness,
tremor, headache, blurred vision, yawning, nausea, constipation, diarrhea, vomiting, dry
mouth, sweating, sexual dysfunction, asthenia, body weight gain.
The less common side effects are arrhythmias, confusion, urinary incontinence, panic
attacks, depersonalization, neuroleptic malignant syndrome-like events, peripheral edema,
acute glaucoma, hepatic disorders, priapism, tinnitus, extra pyramidal reactions and
withdrawal reactions.
Paroxetine should be used with caution in patients with mania, epilepsy, seizures, bone
fracture, diabetes, ECT, glaucoma, cardiac conditions, hyponatraemia, haemorrhage,
renal/hepatic impairment.
Paroxetine is contraindicated in patients with a hypersensitivity to Paroxetine or any of the
Drug interactions
Paroxetine should not be used with pimozide, tyrptophan, drug metabolizing enzyme
inducers /inhibitors, thioridazine, alcohol, fosamprenavir/ritonavir, MAOIs, lithium,
phenytoin/anticonvulsants, warfarin, drugs affecting gastric pH, NSAIDs and acetylsalicylic
Pharmaceutical precautions
Keep away from the reach of children. Store in a cool and dry place protected from light. To
be taken and sold only on the prescription of a registered physician.
Parotin® 10 tablet: Each tablet contains Paroxetine 10mg as Hydrochloride Hemihydrate BP.
Parotin® 20 tablet: Each tablet contains Paroxetine 20mg as Hydrochloride Hemihydrate BP.
Parotin® 10 tablet: Carton of 30 tablets in blister pack.
Parotin® 20 tablet: Carton of 30 tablets in blister pack.
® Registered Trade Mark
ACI Limited
Narayanganj, Bangladesh

Brand: ACI Limited

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